Pharmaceutical Industry

Oral suspensions ● Amoxycillin ● Penicillin ● Omeprazole ● Lansoprazole ● Tetracycline ● Nystatin ● Lidocaine ● Vancomycin ● Hydrocortisone ● Diphenhydramine ● Collagen ● Calcium Carbonate ● Polyethylene Glycol ● Lactose ● Sodium Lauryl Sulfate ● Novamoxin ● Clindamycin ● Erythromycin ● Progesterone ● Methocel ● Psyllium


HOW DOES PER-FIL MEET THE NEEDS OF THE PHARMACEUTICAL / BIOTECH INDUSTRY?
We primarily focus on optimum dose accuracy and the highest dose rates per application.  As with all PER-FIL fillers, dust-free filling is achieved via our patented technologies and design.


Case Study
Different components into each cup.

Objective
To fill two different components of a test kit into each cup.

Problem
Each ingredient must be filled ultra-precisely. Any disparity in the required amount of each diagnostic chemical would give an incorrect test result. Filling by hand was too slow and too unreliable.

Solution
The PER-FIL® STAR-FILL monoblock system was equipped with two nano-Fillers, each designed to dispense the required amount of each chemical into the cup. A load cell is positioned under each nano-Filler for gravimetric operation. The balance controls the auger ensuring optimum fill accuracy control. Automatic container handling is accomplished by a starwheel for precise container positioning under each fill nozzle.


Case Study
Human tissue processing

Objective
To fill human tissue into vials minimizing labor and ensuring fill accuracy.

Problem
Processing and packaging of human skin tissue is extremely labor intensive as bone and tissue is cut and ground and packaged by hand. The training time for employees is 18 months and employee turnover is high due to the tedious nature of the work. This tissue bank sought to simplify the packaging operation by automating the filling and labeling of vials. Machine parts must be auto-cleavable.

Solution
The PER-FIL® nano-W Net Weigh nano-Filler precisely fills the human tissue into vials by simply setting the desired fill weight and pressing a button. A Mettler-Toledo balance controls the auger revolutions to ensure precise dosing. Fill data is downloaded via RS-232 port from the filler PLC to customer supplied PC and ink jet coder which prints lot code and weight on each vial. Product contact parts are easily removed and auto-cleaved.


Case Study
High Speed fill of oral suspension powder.

Objective
High speed filling of a non-free flow oral suspension powder into glass bottles.

Problem
The pharmaceutical manufacturer needed to fill 30 gr. of a non-free flowing dusty powder into glass bottles at rates of 70 bottles per minute with accuracy of +/- 1% or better.

Solution
The PER-FIL® Micro-2C / 4C features four servo driven augers in one common hopper so four bottles are filled at one time. By directly augering the powder into each bottle, we have optimum control over fill accuracy and fill speed. The bottles are lifted at the fill position to insert the nozzle into the bottle ensuring a dust free dispense.


Case Study
Filling fine powder at high production rates.

Objective
To fill plastic bottles with 12 gr. of free flowing Penicillin at rates in excess of 350 cpm.

Problem
The filling and compaction of fine powder into containers at high production rates presents many difficulties: dust, product bridging and inaccurate fills – to name just a few.

Solution
PER-FIL® Model PF-28RCM 30 station ROTARY CONTINUOUS MOTION filling system equipped with ORBITAL FUNNEL VIBRATION to speed up the product flow; VACUUM ASSIST to compact product; and BOTTOM RAIL TAMPING to settle product in container. Checkweigher feedback ensures optimum fill accuracy.


Case Study
Verifiable high accuracy filling.

Objective
Verifiable, high accuracy filling of 210 mg – 3465 mg of Lidocaine and progesterone into glass bottles.

Problem
Empty glass bottles can vary as much as +/- 5 grams, eliminating a checkweigher after the fill as a possibility for ensuring fill accuracy. Customer required automatic filling and container handling.

Solution
PER-FIL® Model MF-SWC features a servo auger filler with conveyor. A load cell is positioned at the fill position. The conveyor chain is lowered for each fill cycle to isolate the bottle on the load cell and allow for fill-by-weight operation. Weight data is downloaded to a customer supplied PLC through an RS-232 port.

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